Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases
نویسندگان
چکیده
منابع مشابه
The brain-specifi c cholesterol 24-hydroxylase (CYP46A1) is a member of the cytochrome P450 superfamily of enzymes that catalyzes the hydroxylation of cholesterol into 24(S)-hydroxycholesterol (24OHC)
This article is available online at http://www.jlr.org The brain-specifi c cholesterol 24-hydroxylase (CYP46A1) is a member of the cytochrome P450 superfamily of enzymes that catalyzes the hydroxylation of cholesterol into 24(S)-hydroxycholesterol (24OHC) ( 1 ). The fl ux of this oxysterol across the blood-brain barrier represents the major mechanism of cholesterol elimination from the brain ha...
متن کاملNeuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis
Impairment in cholesterol metabolism is associated with many neurodegenerative disorders including Alzheimer's disease (AD). However, the lipid alterations underlying neurodegeneration and the connection between altered cholesterol levels and AD remains not fully understood. We recently showed that cholesterol accumulation in hippocampal neurons, induced by silencing Cyp46a1 gene expression, le...
متن کاملCholesterol 24S-hydroxylase (CYP46A1) is of key impor- tance for cholesterol homeostasis in the brain and is re- sponsible for about two-thirds of cholesterol elimination
This article is available online at http://www.jlr.org Cholesterol 24S-hydroxylase (CYP46A1) is of key importance for cholesterol homeostasis in the brain and is responsible for about two-thirds of cholesterol elimination from this organ ( 1, 2 ). Except for the enzyme induction during neonatal stage and a stimulatory effect by oxidative stress, CYP46A1 appeared to be resistant toward a broad s...
متن کاملstudy of cohesive devices in the textbook of english for the students of apsychology by rastegarpour
this study investigates the cohesive devices used in the textbook of english for the students of psychology. the research questions and hypotheses in the present study are based on what frequency and distribution of grammatical and lexical cohesive devices are. then, to answer the questions all grammatical and lexical cohesive devices in reading comprehension passages from 6 units of 21units th...
In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds.
Cytochrome P450 46A1 (CYP46A1, cholesterol 24-hydroxylase) is the enzyme responsible for the majority of cholesterol elimination from the brain. Previously, we found that the anti-HIV drug efavirenz (EFV) can pharmacologically activate CYP46A1 in mice. Herein, we investigated whether CYP46A1 could also be activated by endogenous compounds, including major neurotransmitters. In vitro experiments...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurotherapeutics
سال: 2019
ISSN: 1933-7213,1878-7479
DOI: 10.1007/s13311-019-00731-6